Vaccine equity ensures equal access to vaccines for all, regardless of socioeconomic status or location, focusing on underserved areas. It involves making vaccines affordable, establishing effective distribution, and providing accurate information to combat misinformation. Key challenges include global disparities, logistical issues, and vaccine misinformation. The World Vaccines R&D Conference is key in fostering global collaboration, research, and policies to promote equitable vaccine access, addressing these challenges to improve public health worldwide.