Vaccine durability is the duration of time for which a vaccine provides immunity. It depends on the type of vaccine, the kind of immune response it triggers, and the existence of any variant that might affect its effectiveness. Some vaccines offer lifelong protection, whereas others may require booster doses. Continuous research and surveillance are essential to monitor the durability of vaccines and ensure that the immunity remains effective against the diseases. The World Vaccines R&D Conference contributes to advancing research in this area, fostering global efforts to enhance vaccine longevity and effectiveness.