Vaccine delivery systems are crucial for efficient immunization and optimal immune responses. Some methods used in vaccine delivery include intramuscular, oral, nasal, and needle-free systems. Liposomes, microneedles, and mRNA vaccines with lipid nanoparticles are some of the advanced technologies that improve the stability and effectiveness of vaccines. Innovations in sustained-release systems aim to overcome the barriers of cold chain requirements. Events like the World Vaccines R&D Conference promote global collaboration to enhance vaccine delivery and accessibility worldwide.