Systems vaccinology is an interdisciplinary approach that uses advanced technologies to study and understand the immune system's response to vaccines. It integrates genomics, proteomics, transcriptomics, and computational modeling to identify biomarkers, predict vaccine responses, and design more effective vaccines. This approach focuses on the interactions between the vaccine and the immune system, providing insights into how vaccines induce immunity and how they can be improved. It also helps understand individual variations in vaccine responses, which can be used to personalize vaccination strategies. The World Vaccines R&D Conference supports the advancement of systems vaccine technology, which is driving innovative vaccine development.