This vaccination refers to vaccinating special groups who are predisposed to increased infection risks from age, underlying illness, or exposure from certain activities, and it might involve the geriatric population, pregnant women, babies, people who work in healthcare settings, people who have severe immunity deficiency, or those with chronic illnesses. This kind of vaccine would prevent some patients from having severe cases and some from dying and avoid infection complications. Tailored immunization strategies help ensure those populations receive the right vaccines at the right time. Therefore, the World Vaccines R&D Conference emphasizes a need to provide these at-risk groups with their necessary protection, thereby protecting public health.