The World Vaccines R&D Conference 2025 (WVRDC 2025), held from October 17–19, 2025, in Paris, France, brought together global leaders in vaccine innovation, infectious disease research, and immunology to explore the next frontiers in vaccine science. Centered on advancing breakthroughs through research and collaboration, the conference featured dynamic discussions on mRNA technology, AI-driven vaccine design, and novel immunotherapies. By fostering connections among scientists, industry experts, and policymakers, WVRDC 2025 strengthened global partnerships and set a strong foundation for future innovations in vaccine development and public health preparedness.